For the global analysis we want to describe large clades that differ in some metadata with respect to the rest of the tree.
First we look at the distribution of mosaic variants of the genes mtr and penA, minimum inhibitory concentration (MIC) (categorised into levels high and low) levels, and sex distribution,
The fully annotated tree shows that most of the mosaic variant of mtr clusters in distict part of the tree.
High HIC categories also clusters in some sections of the tree.
The sex distribution does not have major evident clusters when we look at the tree as a whole, but in smaller sections of the tree.
